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Tag: solvent selectivity


2011-1. Selectivity in Reversed-Phase LC Separations, Part II: Solvent-Strength Selectivity

January 1, 2011

A change in the mobile phase strength can be a powerful tool to move peaks in a separation. LCGC 29(1) 28-34 (2011) John W. Dolan

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2010-12. Selectivity in Reversed-Phase LC Separations, Part I: Solvent-Type Selectivity

December 1, 2010

Methanol and acetonitrile are the two most popular organic solvents to use in the mobile phase for reversed-phase liquid chromatography (LC) separations. Tetrahydrofuran is also used to a lesser extent. Why are these solvents the most popular ones? Are there alternative solvents that should be tried? This month’s “LC Troubleshooting” […]

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1995-4. Odds and Ends from the Mailbox

April 1, 1995

Questions about column flushing, recycling and choosing mobile-phase solvents, unexpected peaks, and rust on frits. LCGC 13(4) 302-304 (1995) John W. Dolan

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