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Tag: solvent characteristics


2011-1. Selectivity in Reversed-Phase LC Separations, Part II: Solvent-Strength Selectivity

January 1, 2011

A change in the mobile phase strength can be a powerful tool to move peaks in a separation. LCGC 29(1) 28-34 (2011) John W. Dolan

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2010-12. Selectivity in Reversed-Phase LC Separations, Part I: Solvent-Type Selectivity

December 1, 2010

Methanol and acetonitrile are the two most popular organic solvents to use in the mobile phase for reversed-phase liquid chromatography (LC) separations. Tetrahydrofuran is also used to a lesser extent. Why are these solvents the most popular ones? Are there alternative solvents that should be tried? This month’s “LC Troubleshooting” […]

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2007-8. The Perfect Method, Part III: Adjusting Retention

August 1, 2007

Faster isn’t always better. LCGC 25(8) 704-709 (2007) John W. Dolan

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2007-7. The Perfect Method, Part II: Where to Start?

July 1, 2007

Getting started on the right foot is important for efficient method development. LCGC 25(7) 632-638 (2007) John W. Dolan

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2006-6. The Power of Mobile Phase Strength

June 1, 2006

Nothing’s magic — peaks move in a regular manner when conditions are changes. LCGC 24(6) 570-578 (2006) John W. Dolan

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2000-2. Starting Out Right, Part III — The Role of the Solvent in Controlling Selectivity

February 1, 2000

The chromatographic challenge is to separate two peaks LCGC 18(2) 118-125 (2000) John W. Dolan

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1999-6. How Much Is Too Much?

June 1, 1999

Just how much sample can you load onto a liquid chromatography column? LCGC 17(6) 508-510 (1999) John W. Dolan

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1997-9. Retention Time Problems

September 1, 1997

Retention time instability creates frustrating problems. LCGC 15(9) 826-830 (1997) John W. Dolan

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1996-2. Using a Gradient Scouting Run to Get Started

February 1, 1996

Sometimes knowing where to start is half the battle. LCGC 14(2) 98-102 (1996) John W. Dolan

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1996-1. Injection Problems

January 1, 1996

Just getting the sample into the column in a compatible solvent can be a challenge. LCGC 14(1) 20-24 (1996) John W. Dolan

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