2017-8. Method Adjustment for Gradient Elution
You have to be careful to avoid unwanted results when adjusting gradient conditions. LCGC 35(8) 480-485 (2017) John W. Dolan
Read More →You have to be careful to avoid unwanted results when adjusting gradient conditions. LCGC 35(8) 480-485 (2017) John W. Dolan
Read More →When you want to adjust a United States Pharmacopoeia (USP) method for a different size column or to meet system-suitability criteria that fail, how much of a change can you make without revalidating the method? LCGC 35(6) 368-373 (2017) John W. Dolan
Read More →Are your solvent costs too high? Here are some ideas about how to decrease the amount of mobile phase you use. LCGC 33(10) 752-757 (2015) John W. Dolan
Read More →If scaling isocratic separations is so simple, why is gradient scaling so confusing? LCGC 32(3) 188-193 (2014) John W. Dolan
Read More →What kind of adjustments need to be made when scaling an isocratic method? LCGC 32(2) 98-102 (2014) John W. Dolan
Read More →How can we tell if a liquid chromatography method is working properly? How can a compendial method be adjusted to speed up the run time? LCGC 30(11) 972-977 (2012) Fatos Osmani and John W. Dolan
Read More →Where to place the blame when something goes wrong. LCGC 27(9) 816-821 (2009) John W. Dolan
Read More →Remember the Rule of One — change just one thing at a time LCGC 27(8) 606-610 (2009) John W. Dolan Erratum: LCGC 27(6), p 478. Table 1, in the third column, the next to last line should read 403913, not 36827, and the 36827 should shift down one row.
Read More →LC problems know no national boundaries. LCGC 27(1) 26-34 (2009) John W. Dolan
Read More →Chromatographers worldwide suffer from the same problems. LCGC 25(01) 34-38 (2007) John W. Dolan Erratum: Note that equation 5 for USP tailing factor is not correct. It should read: TF = w(total)/2*w(front).
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