2016-10. Reader’s Questions: Gradient Ghost Peaks
Interfering peaks of high baseline background can compromise the results of gradient liquid chromatography (LC) separations. LCGC 34(10) 778-785 (2016) John W. Dolan
Read More →Interfering peaks of high baseline background can compromise the results of gradient liquid chromatography (LC) separations. LCGC 34(10) 778-785 (2016) John W. Dolan
Read More →Some attributes of large molecules make them behave differently from small molecules in reversed-phase separations. LCGC 32(4) 256-261 (2014) John W. Dolan
Read More →Where do all those extra peaks come from? LCGC 31(8) 604-611 (2013) John W. Dolan
Read More →Can anything be done to correct for baseline drift in gradient separations? LCGC 31(7) 538-543 (2013) John W. Dolan
Read More →Gradient methods can offer unique solutions to separation problems, but transferring a gradient method from the literature, between laboratories, or even within the same laboratory can be a challenging process. LCGC 31(6) 456-463 (2013) John W. Dolan ERRATA: p. 458, righthand column, 2nd full paragraph, second sentence cites reference (4). […]
Read More →Sometimes when changes are made to gradient conditions, the result isn’t what was expected. LCGC 31(5) 382-389 (2013) John W. Dolan ERRATUM: The last word on p. 388 should be “decrease” not “increase.” A change in particle size from 3 microns to 5 should reduce the pressure, not increase it.
Read More →Is it possible to get the same separation under isocratic and gradient conditions? LCGC 31(4) 300-305 (2013) John W. Dolan
Read More →In contrast to isocratic separations, gradient elution sometimes can seem to be counter-intuitive. Yet with the proper perspective, the things we intuitively understand about isocratic methods apply in a similar manner to gradients. LCGC 31(3) 204-209 (2013) John W. Dolan
Read More →For method development or routine analysis, the minimum gradient time may be a limit of throughput. LCGC 29(8) 652-657 (2011) John W. Dolan
Read More →Ghost peaks can be difficult to eliminate when minor peaks are important in an LC Separation. This case study shows how to isolate the source of such peaks. LCGC 29(5) 394-400 (2011) Silvia Sadikin, Dee Dee Zhang, Roger Inloes, Sanjeev Redkar, and John W. Dolan
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