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Tag: column types


2017-5. Count the Cost, Part III: Increasing Resolution by Changing Selectivity

May 1, 2017

Several variables can be used to change selectivity in a liquid chromatography (LC) separation. Here we compare the variables in an effort to prioritize which experiments will be most effective. LCGC 35(5) 306-311 (2017) John W. Dolan See also 2017-3 and 2017-4 for remaining articles in this series.

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2011-3. Selectivity in Reversed-Phase LC Separations, Part III: Column-Type Selectivity

March 1, 2011

How to choose another column to try to solve a separation problem. LCGC 29(3) 236-244 (2011) John W. Dolan

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2009-9. Method or System?

September 1, 2009

Where to place the blame when something goes wrong. LCGC 27(9) 816-821 (2009) John W. Dolan

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2008-11. Extracolumn Effects

November 1, 2008

What’s the big deal about a few microliters of volume? LCGC 26(11) 1092-1098 (2008) John W. Dolan

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2007-10. The Perfect Method, Part V: Changing Column Selectivity

October 1, 2007

How to avoid an expensive shot in the dark. LCGC 25(10) 1014-1020 (2007) John W. Dolan

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2007-7. The Perfect Method, Part II: Where to Start?

July 1, 2007

Getting started on the right foot is important for efficient method development. LCGC 25(7) 632-638 (2007) John W. Dolan

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2005-2. Extracolumn Effects

February 1, 2005

How much tubing can you get away with? LCGC 23(2) 130-135 (2005) John W. Dolan

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2001-12. From the e-Mail Bag

December 1, 2001

John Dolan answers reader’s questions related to columns and methods. LCGC 19(12) 1192-1196 (2001) John W. Dolan

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2001-11. Retaining Polar Compounds

November 1, 2001

Some compounds just won’t stick to the column. LCGC 19(11) 1132-1135 (2001) John W. Dolan

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2000-12. Reducing Column Diameter in Gradient Elution — A Case Study

December 1, 2000

Simply scaling the gradient won’t always work LCGC 18(12) 1228-1232 (2000) John W. Dolan Erratum: Figure 3 and the accompanying discussion is not quite correct. The correct numbers are (assuming that a 150 x 4.6 mm column has a column volume, Vm = 1.5 mL and a 150 x 2.1 […]

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