What should you do if your retention times drop from one injection to the next? A systematic approach to troubleshooting can help to quickly identify the problem source. LCGC 34(4) 254-261 (2016) John W. Dolan
Read More →The potential causes are considered for peak distortion for the first two peaks in the chromatogram. LCGC 33(7) 464-469 (2015) John W. Dolan
Read More →Unexpected results from calibration standards create confusion in a clinical liquid chromatography (LC) method. LCGC 33(5) 312-315 (2015) John W. Dolan
Read More →A stepwise process helps isolate and identify the cause of method failure. LCGC 33(3) 176-181 (2015) John W. Dolan
Read More →The solvent chosen for injection can affect the appearance of chromatograpic peaks. LCGC 30(10) 898-902 (2012) Bandar Alshli and John W. Dolan Erratum: (from 30(12): equation 2 should read: w = 4 tR / N^0.5.With this change, all the calculated values of peak widths and recommended injection volumes should be […]
Read More →What do you do when a peak grows over time?. LCGC 29(6) 486-491 (2011) John W. Dolan
Read More →Ghost peaks can be difficult to eliminate when minor peaks are important in an LC Separation. This case study shows how to isolate the source of such peaks. LCGC 29(5) 394-400 (2011) Silvia Sadikin, Dee Dee Zhang, Roger Inloes, Sanjeev Redkar, and John W. Dolan
Read More →Apply the fundamentals to your problem and the cause may become obvious. Keywords: LCGC 29(2) 136-142 (2011) Kasper Pedersen and John W. Dolan
Read More →There’s more to the data than you might expect. LCGC28(4) 292-300 (2010) Jennifer Birchett and John W. Dolan
Read More →What should you do when a peak is too small or too large? LCGC 28(1) 28-32 (2010) John W. Dolan
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