Introduction to Modern Liquid Chromatography, 3rd Ed
Lloyd R. Snyder, Joseph J. Kirkland, and John W. Dolan; 912 pp.
This carefully considered Third Edition maintains the strengths of the previous edition while significantly modifying its organization in light of recent research and experience. The text begins by introducing the reader to HPLC, its use in relation to other modern separation techniques, and its history, then leads into such specific topics as:
- The basis of HPLC separation and the general effects of different experimental conditions
- Equipment and detection
- The column—the “heart” of the HPLC system
- Reversed-phase separation, normal-phase chromatography, gradient elution, two-dimensional separation, and other techniques
- Computer simulation, qualitative and quantitative analysis, and method validation and quality control
- The separation of large molecules, including both biological and synthetic polymers
- Chiral separations, preparative separations, and sample preparation
- Systematic development of HPLC separations—new to this edition
- Troubleshooting tricks, techniques, and case studies for both equipment and chromatograms
Practical HPLC Method Development, 2nd Ed
Lloyd R. Snyder, Joseph L. Glajch, and Joseph J. Kirkland 800 pp.
This title also incorporates updated discussions of fundamental systems components and practical issues associated with HPLC that were originally introduced in Snyder and Kirkland’s classic work Introduction to Modern Liquid Chromatography. Practical HPLC Method Development represents an ideal instructional tutorial for scientists and students who are just beginning to work with HPLC. The practice-oriented coverage will benefit the experienced analyst as well in developing better HPLC methods faster.
High-Performance Gradient Elution: The Practical Application of the Linear-Solvent-Strength Model
Lloyd Snyder and John Dolan; 496 pp.
This up-to-date, practical, and comprehensive treatment of gradient elution:
- Provides specific, step-by-step recommendations for developing a gradient separation for any sample
- Describes the best approach for troubleshooting problems with gradient methods
- Guides the reader on the equipment used for gradient elution
- Lists which conditions should be varied first during method development, and explains how to interpret scouting gradients
- Explains how to avoid problems in transferring gradient methods
With a focus on the use of linear solvent strength (LSS) theory for predicting gradient LC behavior and separations by reversed-phase HPLC, High-Performance Gradient Elution gives every chromatographer access to this useful tool.
Basic HPLC and CE of Biomolecules
Robert Cunico, Karen Gooding, and Tim Wehr; 388 pp. (paperback)
Written for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers.
Topics covered include:
- HPLC operation
- Method development
- Maintenance and troubleshooting
- Modern trends in HPLC such as quick-turnaround and “greener” methods
- Regulatory aspects
While broad in scope, this book focuses particularly on reversed-phase HPLC, the most common separation mode, and on applications for the pharmaceutical industry, the largest user segment. Accessible to both novice and intermedate HPLC users, information is delivered in a straightforward manner illustrated with an abundance of diagrams, chromatograms, tables, and case studies, and supported with selected key references and Web resources.
With intuitive explanations and clear figures, Modern HPLC for Practicing Scientists is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology
Introduction to Mass Spectrometry: Instrumentation, Applications, and Strategies for Data Interpretation, 4th ed.
J. Throck Watson and O. David Sparkman; 862 pp.
This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry.