Strongly retained sample compounds can caus various changes in the appearance of a chromatogram.
John W. Dolan
Errata: Note that there was a transposition error in this and two associated articles. In the referenced table, the words “Symptom” and “Cause” have been reversed. That is, “Cause” should correlate with the vertical column at the left and “Symptom” with the contents of the table (Pressure, Tailing, etc.). These problems occur in:
V33(11) p. 848, Table 3 (Nov. 2015); V33(12) p. 896, Table 1 (Dec. 2015); V34(1) p. 22, Table 1 (Jan. 2016)
For a corrected online version of this column, see: http://www.chromatographyonline.com/detective-work-part-iii-strong-retention-and-chemical-problems-column